[The role of piRNAs in mouse spermatogenesis.]

Girard, A., Hannon, G. J. (2007) [The role of piRNAs in mouse spermatogenesis.]. J Soc Biol, 201 (4). pp. 411-8.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18533102
DOI: 10.1051/jbio:2007912

Abstract

The Argonaute proteins, which are the direct partners of the small RNAs involved in RNA interference mechanisms, can be divided into two subfamilies, the Argonautes and the Piwis. In animals, the Argonaute subfamily binds 21-22 nucleotide small interfering RNAs (siRNAs) and microRNAs (miRNAs), which direct cleavage and translational inhibition of their target RNAs respectively. The partners of the Piwi proteins are 24-30-nucleotide small RNAs called Piwi-interacting RNAs or piRNAs. In Drosophila, Piwi proteins and piRNAs protect the genome of the germline against selfish elements. Recent studies suggest that this function is conserved in mammals.La famille des Argonautes, les partenaires directs des petits ARNs dans les mecanismes d'interference par l'ARN, se divise en deux sous-groupes : les Argonautes et les Piwis. Chez les animaux, le sous-groupe des Argonautes se lie aux petits ARNs interferents (siARNs) et aux microARNs (miARNs) qui mesurent 21-22 nucleotides et sont responsables du clivage et de l'inhibition traductionnelle des ARNs cibles respectivement. Les proteines Piwis ont pour partenaires de petits ARNs de 24-30 nucleotides appeles Piwi-interacting RNAs ou piARNs. Chez la drosophile, les proteines Piwi et les piARNs protegent le genome de la lignee germinale contre les elements mobiles. Des analyses recentes suggerent que cette fonction est conservee chez les mammiferes.

Item Type: Paper
Additional Information: original article in french English Abstract Journal Article
Subjects: organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Piwi protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > germ cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > germ cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > germ cell

organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > sRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > siRNA
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: CSHL Librarian
Date Deposited: 15 Nov 2011 19:52
Last Modified: 26 Sep 2014 19:17
URI: http://repository.cshl.edu/id/eprint/23018

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