Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex

Dumitriu, D., Cossart, R., Huang, Z. J., Yuste, R. (2007) Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. Cerebral Cortex, 17 (1). pp. 81-91. ISSN 1047-3211

URL: https://www.ncbi.nlm.nih.gov/pubmed/16467567
DOI: 10.1093/cercor/bhj126

Abstract

Neocortical interneurons display great morphological and physiological variability and are ideally positioned to control circuit dynamics, although their exact role is still poorly understood. To better understand this diversity, we have performed a detailed anatomical and physiological characterization of 3 subtypes of visual cortex interneurons, isolated from transgenic mice which express green fluorescent protein in somatostatin, parvalburnin, and neuropeptide Y positive neurons. We find that these 3 groups of interneurons have systematic differences in dendritic and axonal morphologies and also characteristically differ in the frequencies, amplitude, and kinetics of the spontaneous excitatory and inhibitory synaptic currents they receive. Moreover, we detect a correlation between the kinetics of their synaptic inputs and quantitative aspects of their axonal arborizations. This suggests that different interneuron types could channel different temporal patterns of activity. Our results also confirm the importance of the axonal morphology to classify interneurons.

Item Type: Paper
Uncontrolled Keywords: cortex EPSP GABA GFP IPSP DIVERSITY-SERIES HIPPOCAMPAL INTERNEURONS NEOCORTICAL INTERNEURONS GABAERGIC INTERNEURONS TRANSGENIC MICE CEREBRAL-CORTEX CLASSIFICATION NEURONS INHIBITION CELLS
Subjects: bioinformatics > genomics and proteomics > small molecules > GABA
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > green fluorescent protein
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal behavior > visual
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 15 Nov 2011 16:22
Last Modified: 10 Jan 2017 15:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23005

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