Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity

Di Cristo, G., Chattopadhyaya, B., Kuhlman, S. J., Fu, Y., Belanger, M-C., Wu, C. Z., Rutishauser, U., Maffei, L., Huang, Z. J. (2007) Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity. Nat Neurosci, 10 (12). pp. 1569-1577.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18026099
DOI: 10.1038/nn2008

Abstract

Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > small molecules > GABA
bioinformatics > genomics and proteomics > small molecules > polysialic acid
organism description > animal behavior > visual
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 30 Nov 2011 20:38
Last Modified: 08 May 2015 13:36
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23000

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