The blu Blur: mutation of a vesicular glutamate transporter reduces the resolution of zebrafish vision

Demas, J., Cline, H. T. (January 2007) The blu Blur: mutation of a vesicular glutamate transporter reduces the resolution of zebrafish vision. Neuron, 53 (1). pp. 4-6. ISSN 0896-6273 (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/17196524
DOI: 10.1016/j.neuron.2006.12.019

Abstract

Vesicular transporters mediate the packaging of neurotransmitters into synaptic vesicles and can therefore control the amount of neurotransmitter released into the synaptic cleft. In this issue of Neuron, Smear et al. demonstrate that mutation of a vesicular glutamate transporter (Vglut) found in the retinal ganglion cells (RGCs) of zebrafish alters both the synaptic transmission and connectivity between RGCs and their targets, limiting the transfer of visually evoked activity from RGCs and degrading behaviors that depend on high-acuity vision.

Item Type: Paper
Uncontrolled Keywords: Animals Glutamic Acid/metabolism Mutation/ genetics Neural Pathways/cytology/metabolism/physiopathology Retinal Ganglion Cells/ metabolism/ultrastructure Synaptic Transmission/ genetics Vesicular Glutamate Transport Proteins/ genetics Vision/genetics Vision Disorders/genetics/metabolism/physiopathology Zebrafish/anatomy & histology/ metabolism
Subjects: organism description > animal behavior > visual > seeing
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organism description > animal behavior > vision
organism description > animal behavior > visual
organism description > animal > fish > zebrafish
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: CSHL Librarian
Date: 4 January 2007
Date Deposited: 30 Nov 2011 20:06
Last Modified: 22 Mar 2018 16:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22996

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