Refining the roles of GABAergic signaling during neural circuit formation

Akerman, C. J., Cline, H. T. (2007) Refining the roles of GABAergic signaling during neural circuit formation. Trends in Neurosciences, 30 (8). pp. 382-389. ISSN 0166-2236

URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
DOI: 10.1016/j.tins.2007.06.002

Abstract

Our understanding of the role of GABA signaling in circuit development is rapidly expanding. Here, we review three recent refinements in our understanding of the diverse roles that GABA plays at different stages of neural circuit formation. First, we discuss recent evidence that depolarizing GABA plays at least a permissive role in promoting both excitatory and inhibitory synaptogenesis in developing neurons (including newly generated neurons in the adult). Next, we discuss recent evidence that GABAergic circuits sculpt the temporal and spatial aspects of synaptic integration. Consequently, early developmental events affecting the establishment of GABAergic circuits will control subsequent activity-dependent refinements of information processing and circuit function. In the third section, we review recent evidence of molecular mechanisms by which GABAergic signaling plays a role in the regulation of the balance between GABAergic and glutamatergic transmission in developing circuits. Throughout the review, we concentrate on the effects of the signaling by GABA(A) receptors. as told from the point of view of the GABA-responsive cells, and do not discuss mechanisms that govern GABA release or activity of GABAergic neurons per se.

Item Type: Paper
Uncontrolled Keywords: DENDRITIC ARBOR GROWTH LONG-TERM POTENTIATION CA1 PYRAMIDAL NEURONS FEEDFORWARD INHIBITION IN-VIVO SYNAPTIC INHIBITION GABA(A) RECEPTORS Cortical Neurons Subplate neurons PROGENITOR CELLS
Subjects: bioinformatics > genomics and proteomics > small molecules > GABA
bioinformatics > genomics and proteomics > small molecules > GABAergic
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: CSHL Librarian
Date Deposited: 02 Dec 2011 15:23
Last Modified: 02 Dec 2011 15:23
URI: http://repository.cshl.edu/id/eprint/22956

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