Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by Homer1a induction

Van Keuren-Jensen, K., Cline, H. T. (2006) Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by Homer1a induction. Journal of Neuroscience, 26 (29). pp. 7575-7580. ISSN 02706474

URL: http://www.jneurosci.org/cgi/content/full/26/29/75...
DOI: 10.1523/JNEUROSCI.5083-05.2006

Abstract

Brief metabotropic glutamate receptor (mGluR) activation leads to plasticity of AMPA receptor (AMPAR) synaptic transmission. To test whether mGluR-mediated plasticity of AMPAR transmission is influenced by recent neuronal activity, we manipulated visual activity in Xenopus laevis tadpoles in vivo. We compared mGluR-mediated plasticity of AMPAR transmission in optic tectal cells of tadpoles with low levels of previous synaptic activity (overnight in the dark) to transmission in neurons from animals after 4 h of constant visual stimulation. mGluR-mediated plasticity of AMPA transmission was significantly decreased in neurons with recent activity. We tested the role of the activity-regulated mGluR scaffolding protein Homer1a in modulating mGluR-mediated changes in AMPAR transmission. We found that, by changing the ratios of Homer1a to Homer1b in vivo, by either induction of endogenous Homer1a by visual activity or ectopic expression of Homer1a or Homer1b, we could change the direction of mGluR-mediated plasticity. This is the first evidence that mGluR-mediated changes in AMPA transmission can be regulated by Homer proteins in response to physiologically relevant stimuli. Copyright © 2006 Society for Neuroscience.

Item Type: Paper
Uncontrolled Keywords: AMPA receptor carrier protein metabotropic receptor nerve cell plasticity synaptic transmission vision Carrier Proteins Neuronal Plasticity Receptors AMPA Receptors Metabotropic Glutamate Synaptic Transmission Vision
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > glutamate receptor
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organism description > animal behavior > vision
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: CSHL Librarian
Date Deposited: 06 Dec 2011 19:04
Last Modified: 06 Dec 2011 19:04
URI: http://repository.cshl.edu/id/eprint/22921

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