Protein tyrosine phosphatases: from genes, to function, to disease

Tonks, N. K. (November 2006) Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol, 7 (11). pp. 833-46. ISSN 1471-0072 (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/17057753
DOI: 10.1038/nrm2039

Abstract

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.

Item Type: Paper
Uncontrolled Keywords: Binding Sites Gene Expression Regulation Humans Ligands Models, Biological Neoplasms enzymology etiology Oxidation-Reduction Protein-Tyrosine-Phosphatase classification genetics physiology Signal Transduction Structure-Activity Relationship Tumor Suppressor Proteins genetics physiology Tyrosine metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein phosphatase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: CSHL Librarian
Date: November 2006
Date Deposited: 08 Dec 2011 18:37
Last Modified: 21 Feb 2017 20:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22915

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