Molecular taxonomy of major neuronal classes in the adult mouse forebrain

Sugino, K., Hempel, C. M., Miller, M. N., Hattox, A. M., Shapiro, P., Wu, C., Huang, Z. J., Nelson, S. B. (2006) Molecular taxonomy of major neuronal classes in the adult mouse forebrain. Nature Neuroscience, 9 (1). pp. 99-107. ISSN 10976256

URL: http://www.ncbi.nlm.nih.gov/pubmed/16369481
DOI: 10.1038/nn1618

Abstract

Identifying the neuronal cell types that comprise the mammalian forebrain is a central unsolved problem in neuroscience. Global gene expression profiles offer a potentially unbiased way to assess functional relationships between neurons. Here, we carried out microarray analysis of 12 populations of neurons in the adult mouse forebrain. Five of these populations were chosen from cingulate cortex and included several subtypes of GABAergic interneurons and pyramidal neurons. The remaining seven were derived from the somatosensory cortex, hippocampus, amygdala and thalamus. Using these expression profiles, we were able to construct a taxonomic tree that reflected the expected major relationships between these populations, such as the distinction between cortical interneurons and projection neurons. The taxonomic tree indicated highly heterogeneous gene expression even within a single region. This dataset should be useful for the classification of unknown neuronal subtypes, the investigation of specifically expressed genes and the genetic manipulation of specific neuronal circuit elements. © 2006 Nature Publishing Group.

Item Type: Paper
Uncontrolled Keywords: brain nerve cell cell type forebrain taxonomy
Subjects: bioinformatics > genomics and proteomics > Mapping and Rendering
bioinformatics > genomics and proteomics > analysis and processing > microarray gene expression processing
organs, tissues, organelles, cell types and functions > tissues types and functions > forebrain
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 08 Dec 2011 16:47
Last Modified: 10 May 2013 18:37
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22910

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