Argonaute and RNA--getting into the groove

Song, J. J., Joshua-Tor, L. (2006) Argonaute and RNA--getting into the groove. Curr Opin Struct Biol, 16 (1). pp. 5-11. ISSN 0959-440X (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/16434185
DOI: 10.1016/j.sbi.2006.01.010

Abstract

RNAi has made an enormous impact on biology in a very short period of time. It became an extraordinarily useful and simple tool for gene silencing, even as its fascinating mechanism was gradually unraveling. Understanding the mechanism of RNAi-related pathways, including both transcriptional and posttranscriptional gene silencing and even processes such as DNA elimination in Tetrahymena, have benefited from an incredible marriage of genetics, biochemistry, molecular biology, bioinformatics and finally structural biology. Structural biology played a key role in deciphering the role that a central player--the Argonaute protein--has in all RNAi processes.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > design > nucleic acid design > RNAI Design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > argonaute proteins
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > post transcriptional modification
structural biology
CSHL Authors:
Communities: CSHL labs > Joshua-Tor lab
Watson School > Publications
Depositing User: CSHL Librarian
Date Deposited: 08 Dec 2011 16:14
Last Modified: 26 Sep 2014 15:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22905

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