Sparse odor coding in awake behaving mice

Rinberg, D. A., Koulakov, A. A., Gelperin, A. (August 2006) Sparse odor coding in awake behaving mice. J Neurosci, 26 (34). pp. 8857-65. ISSN 1529-2401 (Electronic)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/16928875
DOI: 10.1523/jneurosci.0884-06.2006

Abstract

Responses of mitral cells represent the results of the first stage of odor processing in the olfactory bulb. Most of our knowledge about mitral cell activity has been obtained from recordings in anesthetized animals. We compared odor-elicited changes in firing rate of mitral cells in awake behaving mice and in anesthetized mice. We show that odor-elicited changes in mitral cell firing rate were larger and more frequently observed in the anesthetized than in the awake condition. Only 27% of mitral cells that showed a response to odors in the anesthetized state were also odor responsive in the awake state. The amplitude of their response in the awake state was smaller, and some of the responses changed sign compared with their responses in the anesthetized state. The odor representation in the olfactory bulb is therefore sparser in awake behaving mice than in anesthetized preparations. A qualitative explanation of the mechanism responsible for this phenomenon is proposed.

Item Type: Paper
Uncontrolled Keywords: Anesthesia Animals Electrophysiology Male Mice Mice Inbred C57BL Neurons Afferent physiology Odors Olfactory Bulb cytology physiology Smell physiology Wakefulness physiology
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > mitral cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > mitral cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > mitral cell

organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Koulakov lab
Depositing User: CSHL Librarian
Date: 23 August 2006
Date Deposited: 08 Dec 2011 20:40
Last Modified: 06 Nov 2017 21:09
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22886

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