Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis

Reginato, M. J., Muthuswamy, S. K. (2006) Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Journal of Mammary Gland Biology and Neoplasia, 11 (3-4). pp. 205-211. ISSN 10833021

URL: https://www.ncbi.nlm.nih.gov/pubmed/17115263
DOI: 10.1007/s10911-006-9030-4

Abstract

The lumens present in ductal structures are required for transport of fluids and air. Studies in model organisms and cells in culture suggest that lumens can be generated by multiple mechanisms including apoptosis of centrally located cells, and re-modeling of epithelia. Several studies point to a role for apoptosis during lumen formation in the mammary ducts. However, a role for other mechanisms during lumen formation in the mammary ducts is largely unexplored. Understanding how lumens are formed and maintained free of cells is of clinical importance because filling of the luminal space is associated with cancer and inflammation. Thus, further investigation can lead to new diagnostic and therapeutic opportunities. © Springer Science+Business Media, LLC 2006.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > organs types and functions > breast
diseases & disorders > cancer > cancer types > breast cancer
organs, tissues, organelles, cell types and functions > tissues types and functions > ductal structure
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: CSHL Librarian
Date: 2006
Date Deposited: 12 Dec 2011 15:54
Last Modified: 27 Apr 2018 14:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22883

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