Nogueira, F. T., Sarkar, A. K., Chitwood, D. H., Timmermans, M. C. (2006) Organ Polarity in Plants Is Specified through the Opposing Activity of Two Distinct Small Regulatory RNAs. Cold Spring Harbor Symposia on Quantitative Biology, 71. pp. 157-64. ISSN 00917451 (ISSN)
Abstract
Small RNAs and their targets form complex regulatory networks that control cellular and developmental processes in multicellular organisms. In plants, dorsoventral (adaxial/abaxial) patterning provides a unique example of a developmental process in which early patterning decisions are determined by small RNAs. A gradient of microRNA166 on the abaxial/ventral side of the incipient leaf restricts the expression of adaxial/dorsal determinants. Another class of small RNAs, the TAS3-derivated trans-acting short-interfering RNAs (ta-siRNAs), are expressed adaxially and repress the activity of abaxial factors. Loss of maize leafbladeless1 (lbl1) function, a key component of the ta-siRNA biogenesis pathway, leads to misexpression of miR166 throughout the initiating leaf, implicating ta-siRNAs in the spatiotemporal regulation of miR166. The spatial restriction of tasiRNA biogenesis components suggests that this pathway may act non-cell-autonomously in the meristem and possibly contributes to the classic meristem-borne adaxializing Sussex signal. Here, we discuss the key participants in adaxial/abaxial patterning and point out the intriguing possibility that organ polarity in plants is established by the opposing action of specific ta-siRNAs and miRNAs.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Arabidopsis genetics growth & development Body Patterning genetics MicroRNAs genetics Models Genetic Molecular Sequence Data Plant Leaves growth & development Plant Proteins genetics Plants genetics growth & development RNA Plant genetics RNA Small Interfering genetics Sequence Homology Amino Acid Signal Transduction genetics |
| Subjects: | organism description > plant behavior organism description > plant bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > sRNA |
| CSHL Authors: | |
| Communities: | CSHL labs > Timmermans lab School of Biological Sciences > Publications |
| Depositing User: | CSHL Librarian |
| Date: | 2006 |
| Date Deposited: | 09 Dec 2011 17:41 |
| Last Modified: | 19 Sep 2014 18:48 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22873 |
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