p63: oncogene or tumor suppressor?

Mills, A. A. (February 2006) p63: oncogene or tumor suppressor? Curr Opin Genet Dev, 16 (1). pp. 38-44. ISSN 0959-437X (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/16359856
DOI: 10.1016/j.gde.2005.12.001

Abstract

p53, the original member of the family of genes now known to include p63 and p73, was first heralded as an oncogene because of its potent transformation capabilities and its robust expression in human tumors. However, it was later discovered that only mutant p53 was oncogenic, and that wild type p53 functioned as a tumor suppressor. Decades later, p63, the newest member of this gene family, is involved in a similar controversy: is p63 an oncogene or a tumor suppressor? Recent progress on understanding the in vivo role of p63 in cancer has focused primarily on investigating its involvement in the tumor-suppressive mechanism of apoptosis, by analyzing mouse models to assess its tumor-suppressive capabilities, and by assessing its expression in human cancers.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis genetics DNA-Binding Proteins Genes Tumor Suppressor Genes p53 Humans Mice Mice Knockout Models Genetic Neoplasms etiology genetics pathology Oncogenes Phosphoproteins deficiency genetics Trans-Activators deficiency genetics Tumor Suppressor Proteins
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: CSHL Librarian
Date: February 2006
Date Deposited: 12 Dec 2011 19:12
Last Modified: 02 Feb 2017 17:29
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22862

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