Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules

Huang, Z. J. (2006) Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules. Nat Neurosci, 9 (2). pp. 163-166.

URL: http://www.ncbi.nlm.nih.gov/pubmed/16439983
DOI: 10.1038/nn1638

Abstract

In vertebrate nervous systems, different classes of synaptic inputs are often segregated into restricted compartments of target neurons. For example, distinct types of GABAergic interneurons preferentially innervate subcellular domains and have been implicated in the precise temporal regulation of integration within neurons and activity within networks. Recent studies suggest that the subcellular segregation of different classes of GABAergic synapses is largely genetically determined. The localization and signaling of L1 family immunoglobulin proteins recruited by ankyrin-based membrane adaptors might serve as compartmental labels, which contribute to subcellular synapse organization in cerebellar Purkinje neurons.

Item Type: Paper
Uncontrolled Keywords: Animals Ankyrins metabolism Models Neurological Neural Cell Adhesion Molecule L1/ metabolism Purkinje Cells metabolism ultrastructure Research Support, N.I.H. Extramural Research Support Non-U.S. Gov't Synapses metabolism ultrastructure gamma-Aminobutyric Acid metabolism
Subjects: bioinformatics > genomics and proteomics > small molecules > GABAergic
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > immunoglobulin proteins
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 14 Dec 2011 15:24
Last Modified: 01 Mar 2013 14:59
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22826

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