GABAB receptor isoforms caught in action at the scene

Huang, Z. J. (2006) GABAB receptor isoforms caught in action at the scene. Neuron, 50 (4). pp. 521-4. ISSN 0896-6273 (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/16701201
DOI: 10.1016/j.neuron.2006.05.005

Abstract

The metabotropic GABAB receptors mediate slow synaptic inhibition and consist of heterodimers of GABAB1 and GABAB2 subunits. The only known molecular diversity of the GABAB receptors arises from the two GABAB1 isoforms, but its functional significance has been unclear. Two studies in this issue of Neuron now demonstrate that GABAB1a and GABAB1b show strategically distinct subcellular localization and physiological action.

Item Type: Paper
Uncontrolled Keywords: Animals Brain physiology Humans Neurons metabolism Protein Isoforms physiology Receptors GABA-B physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics > heterochromatin
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein receptor
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 14 Dec 2011 15:17
Last Modified: 10 Jan 2017 17:00
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22825

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving