Fluoxetine targets early progenitor cells in the adult brain

Encinas, J. M., Vaahtokari, A., Enikolopov, G. N. (2006) Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A, 103 (21). pp. 8233-8. ISSN 0027-8424 (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/16702546
DOI: 10.1073/pnas.0601992103

Abstract

Chronic treatment with antidepressants increases neurogenesis in the adult hippocampus. This increase in the production of new neurons may be required for the behavioral effects of antidepressants. However, it is not known which class of cells within the neuronal differentiation cascade is targeted by the drugs. We have generated a reporter mouse line, which allows identification and classification of early neuronal progenitors. It also allows accurate quantitation of changes induced by neurogenic agents in these distinct subclasses of neuronal precursors. We use this line to demonstrate that the selective serotonin reuptake inhibitor antidepressant fluoxetine does not affect division of stem-like cells in the dentate gyrus but increases symmetric divisions of an early progenitor cell class. We further demonstrate that these cells are the sole class of neuronal progenitors targeted by fluoxetine in the adult brain and suggest that the fluoxetine-induced increase in new neurons arises as a result of the expansion of this cell class. This finding defines a cellular target for antidepressant drug therapies.

Item Type: Paper
Uncontrolled Keywords: Animals Antidepressive Agents pharmacology Brain metabolism Cell Differentiation Dentate Gyrus metabolism Fluoxetine pharmacology Mice Mice Transgenic Mitosis Models Biological Neurons metabolism Serotonin Uptake Inhibitors pharmacology Stem Cells cytology drug effects metabolism
Subjects: bioinformatics > quantitative biology
diseases & disorders > mental disorders > mood disorders > depression
therapies > fluoxetine
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: CSHL Librarian
Date Deposited: 15 Dec 2011 17:09
Last Modified: 01 Mar 2017 15:43
PMCID: PMC1461404
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22786

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