The proteasome: a utility tool for transcription?

Collins, G. A., Tansey, W. P. (April 2006) The proteasome: a utility tool for transcription? Curr Opin Genet Dev, 16 (2). pp. 197-202. ISSN 0959-437X (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/16503126
DOI: 10.1016/j.gde.2006.02.009

Abstract

A growing body of evidence demonstrates that the components of the proteasome are involved directly and mechanistically in the regulation of gene transcription. Proteolytic activities of the proteasome are important for establishing limits for transcription, for promoting the exchange of transcription factors on chromatin, and possibly for facilitating multiple rounds of transcription initiation. Non-proteolytic activities of the proteasome are important for co-activator recruitment, transcriptional elongation, and histone modification. Here, we discuss different ways in which the proteasome can influence transcription, and argue that its unique combination of biological activities makes it ideally suited to act at multiple stages in the transcription process.

Item Type: Paper
Uncontrolled Keywords: Animals Humans Models Biological Models Chemical Proteasome Endopeptidase Complex chemistry metabolism Transcription Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Tansey lab
Watson School > Publications
Depositing User: CSHL Librarian
Date: April 2006
Date Deposited: 19 Dec 2011 18:47
Last Modified: 19 Sep 2014 16:10
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22775

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