p63 regulates an adhesion programme and cell survival in epithelial cells

Carroll, D. K., Carroll, J. S., Leong, C. O., Cheng, F., Brown, M., Mills, A. A., Brugge, J. S., Ellisen, L. W. (June 2006) p63 regulates an adhesion programme and cell survival in epithelial cells. Nature Cell Biology, 8 (6). pp. 551-561. ISSN 14657392

URL: https://www.ncbi.nlm.nih.gov/pubmed/16715076
DOI: 10.1038/ncb1420

Abstract

p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates. By characterising transcriptional changes and cellular effects following modulation of p63 expression, we have defined a vital role for p63 in cellular adhesion. Knockdown of p63 expression caused downregulation of cell adhesion-associated genes, cell detachment and anoikis in mammary epithelial cells and keratinocytes. Conversely, overexpression of the TAp63? or ?Np63? isoforms of p63 upregulated cell adhesion molecules, increased cellular adhesion and conferred resistance to anoikis. Apoptosis induced by loss of p63 was rescued by signalling downstream of ?4 integrin. Our results implicate p63 as a key regulator of cellular adhesion and survival in basal cells of the mammary gland and other stratified epithelial tissues. © 2006 Nature Publishing Group.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > organs types and functions > breast
organs, tissues, organelles, cell types and functions > tissues types and functions > epithelium
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: CSHL Librarian
Date: June 2006
Date Deposited: 19 Dec 2011 16:34
Last Modified: 02 Feb 2017 17:25
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22766

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