Slugging it out: fine tuning the p53-PUMA death connection

Zilfou, J. T., Spector, M. S., Lowe, S. W. (2005) Slugging it out: fine tuning the p53-PUMA death connection. Cell, 123 (4). pp. 545-8. ISSN 0092-8674 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/16286002
DOI: 10.1016/j.cell.2005.11.003

Abstract

In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription factor SLUG is induced by p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage. SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53 (Chi-puk et al., 2005).

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis physiology Apoptosis Regulatory Proteins physiology DNA Damage Hematopoietic Stem Cells physiology radiation effects Humans Mice Models Biological Repressor Proteins physiology Transcription Factors physiology Tumor Suppressor Protein p53 physiology Tumor Suppressor Proteins physiology bcl-2-Associated X Protein physiology bcl-X Protein physiology
Subjects: diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > hematopoietic cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > hematopoietic cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > hematopoietic cell

therapies > stem cells
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Lowe lab
CSHL labs > Spector lab
Depositing User: CSHL Librarian
Date Deposited: 20 Dec 2011 17:00
Last Modified: 01 Mar 2013 21:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22746

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