From worm to human: bioinformatics approaches to identify FOXO target genes

Xuan, Z., Zhang, M. Q. (January 2005) From worm to human: bioinformatics approaches to identify FOXO target genes. Mech Ageing Dev, 126 (1). pp. 209-15. ISSN 0047-6374 (Print)

URL: http://www.scopus.com/record/display.url?eid=2-s2....
DOI: 10.1016/j.mad.2004.09.021

Abstract

Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications.

Item Type: Paper
Uncontrolled Keywords: Animals Computational Biology methods Forkhead Transcription Factors Gene Expression Regulation genetics/physiology Humans Nuclear Proteins genetics/metabolism Response Elements genetics Sequence Analysis, DNA methods Signal Transduction genetics physiology Transcription Factors genetics metabolism
Subjects: bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > cis-regulatory elements
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Zhang lab
Depositing User: CSHL Librarian
Date: January 2005
Date Deposited: 21 Dec 2011 17:07
Last Modified: 21 Dec 2011 17:09
URI: http://repository.cshl.edu/id/eprint/22737

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving