Condensins: organizing and segregating the genome

Hirano, T. (2005) Condensins: organizing and segregating the genome. Curr Biol, 15 (7). R265-75. ISSN 0960-9822 (Print)

URL: http://www.scopus.com/record/display.url?eid=2-s2....
DOI: 10.1016/j.cub.2005.03.037

Abstract

Condensins are multi-subunit protein complexes that play a central role in mitotic chromosome assembly and segregation. The complexes contain 'structural maintenance of chromosomes' (SMC) ATPase subunits, and induce DNA supercoiling and looping in an ATP-hydrolysis-dependent manner in vitro. Vertebrate cells have two different condensin complexes, condensins I and II, each containing a unique set of regulatory subunits. Condensin II participates in an early stage of chromosome condensation within the prophase nucleus. Condensin I gains access to chromosomes only after the nuclear envelope breaks down, and collaborates with condensin II to assemble metaphase chromosomes with fully resolved sister chromatids. The complexes also play critical roles in meiotic chromosome segregation and in interphase processes such as gene repression and checkpoint responses. In bacterial cells, ancestral forms of condensins control chromosome dynamics. Dissecting the diverse functions of condensins is likely to be central to our understanding of genome organization, stability and evolution.

Item Type: Paper
Uncontrolled Keywords: Adenosine Triphosphatases metabolism physiology Cell Cycle Proteins metabolism physiology Chromosome Segregation physiology DNA-Binding Proteins genetics metabolism physiology Evolution, Molecular Gene Expression Regulation Genome Kinetochores physiology Models Biological Multiprotein Complexes Phylogeny
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > condensin complex
CSHL Authors:
Depositing User: CSHL Librarian
Date Deposited: 12 Jan 2012 19:42
Last Modified: 12 Jan 2012 19:42
URI: http://repository.cshl.edu/id/eprint/22596

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