A conserved element in Myc that negatively regulates its proapoptotic activity

Herbst, A., Hemann, M. T., Tworkowski, K. A., Salghetti, S. E., Lowe, S. W., Tansey, W. P. (February 2005) A conserved element in Myc that negatively regulates its proapoptotic activity. EMBO Rep, 6 (2). pp. 177-83. ISSN 1469-221X (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/15678160
DOI: 10.1038/sj.embor.7400333

Abstract

Myc is an oncoprotein transcription factor that promotes cell proliferation and apoptosis. Analysis of highly conserved elements within vertebrate Myc proteins has been instrumental in defining the functions of the Myc protein. Here, we probe the role of a highly conserved, but little studied, element within the central region of c-Myc, termed 'Myc box III' (MbIII). We show that MbIII is important for transcriptional repression by Myc, and for transformation both in vitro and in a mouse model of lymphomagenesis. Curiously, disruption of MbIII decreases transformation activity by increasing the efficiency with which Myc can induce apoptosis, suggesting that MbIII is a negative regulator of programmed cell death. These findings reveal a role for MbIII in Myc biology, and establish that the oncogenic capacity of Myc is linked directly to its ability to temper the apoptotic response.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis physiology Cell Proliferation Gene Expression Regulation physiology Humans Lymphoma etiology pathology Mice Protein Structure Tertiary Proto-Oncogene Proteins c-myc genetics metabolism Transcription Genetic physiology
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Lowe lab
CSHL labs > Tansey lab
Depositing User: CSHL Librarian
Date: February 2005
Date Deposited: 12 Jan 2012 19:09
Last Modified: 03 May 2018 20:40
PMCID: PMC1299243
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22592

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