Are spatial positions of dendritic and axonal branches correlated or independent?

Stepanyants, A., Tamas, G., Chklovskii, D. B. (June 2004) Are spatial positions of dendritic and axonal branches correlated or independent? Neurocomputing, 58-60. pp. 477-485. ISSN 0925-2312

URL: http://apps.isiknowledge.com/InboundService.do?Fun...
DOI: 10.1016/j.neucom.2004.01.084

Abstract

Because direct investigation of synaptic connectivity is difficult, neurobiologists often resort to indirect methods. One method is to infer connectivity from the densities of axonal and dendritic arbors, and the arbor overlap volume. This method is valid only under the assumption that spatial positions of dendritic and axonal branches are uncorrelated on a micrometer lengthscale. We test this assumption by using 3D reconstructions of neuronal pairs from the rat neocortex. We find that the positions of GABAergic interneuron axons are correlated with their targets, while the positions of pyramidal neuron axons are independent of their targets. (C) 2004 Elsevier B.V. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: connectivity cortex excitatory inhibitory SYNAPTIC CONNECTIVITY synaptic connectivity CORTEX cortex INTERNEURONS interneurons PLASTICITY plasticity MORPHOLOGY morphology SPINES spines
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
CSHL Authors:
Communities: CSHL labs > Chklovskii lab
Depositing User: CSHL Librarian
Date: June 2004
Date Deposited: 25 Jan 2012 14:43
Last Modified: 20 Apr 2012 20:39
URI: http://repository.cshl.edu/id/eprint/22491

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