Intrinsic tumour suppression

Lowe, S. W., Cepero, E., Evan, G. (November 2004) Intrinsic tumour suppression. Nature, 432 (7015). pp. 307-15. ISSN 1476-4687 (Electronic)

URL: http://www.nature.com/nature/journal/v432/n7015/fu...
DOI: 10.1038/nature03098

Abstract

Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis Drug Resistance Neoplasm Humans Neoplasms genetics pathology Oncogene Proteins genetics metabolism Tumor Suppressor Protein p53 metabolism
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: CSHL Librarian
Date: 18 November 2004
Date Deposited: 01 Feb 2012 14:39
Last Modified: 01 Feb 2012 14:39
URI: http://repository.cshl.edu/id/eprint/22428

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