MicroRNAs: Small RNAs with a big role in gene regulation

He, L., Hannon, G. J. (August 2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nature Reviews Genetics, 5 (8). pp. 522-532. ISSN 1471-0056

URL: https://www.ncbi.nlm.nih.gov/pubmed/15211354
DOI: 10.1038/nrg1379

Abstract

MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a sequence-specific manner. The two founding members of the microRNA family were originally identified in Caenorhabditis elegans as genes that were required for the timed regulation of developmental events. Since then, hundreds of microRNAs have been identified in almost all metazoan genomes, including worms, flies, plants and mammals. MicroRNAs have diverse expression patterns and might regulate various developmental and physiological processes. Their discovery adds a new dimension to our understanding of complex gene regulatory networks.

Item Type: Paper
Uncontrolled Keywords: DOUBLE-STRANDED-RNA double stranded RNA C-ELEGANS C-Elegans CAENORHABDITIS-ELEGANS Caenorhabditis Elegans MESSENGER-RNA messenger RNA DEVELOPMENTAL SWITCH developmental switch EFFECTOR COMPLEXES effector complexes PAZ DOMAIN PAZ Domain INTERFERENCE interference ARABIDOPSIS Arabidopsis DROSOPHILA Drosophila
Subjects: bioinformatics > genomics and proteomics > annotation > map annotation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mRNA dynamics
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: CSHL Librarian
Date: August 2004
Date Deposited: 01 Feb 2012 18:23
Last Modified: 02 Dec 2016 15:57
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22384

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