Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs

Di Cristo, G., Wu, C., Chattopadhyaya, B., Ango, F., Knott, G., Welker, E., Svoboda, K., Huang, Z. J. (2004) Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nature Neuroscience, 7 (11). pp. 1184-6. ISSN 1546-1726 (Electronic)1097-6256 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15475951
DOI: 10.1038/nn1334

Abstract

Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.

Item Type: Paper
Uncontrolled Keywords: Afferent Pathways physiology Analysis of Variance Animals Cell Size Cell Surface Extensions physiology Chi-Square Distribution Interneurons physiology Mice Mice Transgenic Models Neurological Organ Culture Techniques Parvalbumins genetics Pyramidal Cells cytology physiology Somatostatin genetics Synapses classification physiology Thalamus physiology Visual Cortex cytology physiology gamma-Aminobutyric Acid metabolism
Subjects: bioinformatics > genomics and proteomics > small molecules > GABAergic
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: CSHL Librarian
Date Deposited: 09 Feb 2012 17:33
Last Modified: 10 May 2013 18:48
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22362

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