RNase III enzymes and the initiation of gene silencing

Carmell, M. A., Hannon, G. J. (March 2004) RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol, 11 (3). pp. 214-8. ISSN 1545-9993 (Print)

URL: https://www.ncbi.nlm.nih.gov/pubmed/14983173
DOI: 10.1038/nsmb729

Abstract

Our understanding of RNA interference has been enhanced by new data concerning RNase III molecules. The role of Dicer has previously been established in RNAi as the originator of 22-mers characteristic of silencing phenomena. Recently, a related RNAse III enzyme, Drosha, has surfaced as another component of the RNAi pathway. In addition to biochemistry, protein structures have proven to be helpful in deciphering the enzymology of RNase III molecules.

Item Type: Paper
Uncontrolled Keywords: Gene Silencing MicroRNAs genetics metabolism Models Genetic RNA Interference RNA Small Interfering genetics metabolism Ribonuclease III metabolism physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: CSHL Librarian
Date: March 2004
Date Deposited: 14 Feb 2012 17:20
Last Modified: 02 Dec 2016 19:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/22336

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