Complex Propagation Patterns Characterize Human Cortical Activity during Slow-Wave Sleep

Hangya, B., Tihanyi, B. T., Entz, L., Fabo, D., Eross, L., Wittner, L., Jakus, R., Varga, V., Freund, T. F., Ulbert, I. (June 2011) Complex Propagation Patterns Characterize Human Cortical Activity during Slow-Wave Sleep. Journal of Neuroscience, 31 (24). pp. 8770-8779. ISSN 0270-6474

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URL: http://www.ncbi.nlm.nih.gov/pubmed/21677161
DOI: 10.1523/jneurosci.1498-11.2011

Abstract

Cortical electrical activity during nonrapid eye movement (non-REM) sleep is dominated by slow-wave activity (SWA). At larger spatial scales (similar to 2-30 cm), investigated by scalp EEG recordings, SWA has been shown to propagate globally over wide cortical regions as traveling waves, which has been proposed to serve as a temporal framework for neural plasticity. However, whether SWA dynamics at finer spatial scales also reflects the orderly propagation has not previously been investigated in humans. To reveal the local, finer spatial scale (similar to 1-6 cm) patterns of SWA propagation during non-REM sleep, electrocorticographic (ECoG) recordings were conducted from subdurally implanted electrode grids and a nonlinear correlation technique [mutual information (MI)] was implemented. MI analysis revealed spatial maps of correlations between cortical areas demonstrating SWA propagation directions, speed, and association strength. Highest correlations, indicating significant coupling, were detected during the initial positive-going deflection of slow waves. SWA propagated predominantly between adjacent cortical areas, albeit spatial noncontinuities were also frequently observed. MI analysis further uncovered significant convergence and divergence patterns. Areas receiving the most convergent activity were similar to those with high divergence rate, while reciprocal and circular propagation of SWA was also frequent. We hypothesize that SWA is characterized by distinct attributes depending on the spatial scale observed. At larger spatial scales, the orderly SWA propagation dominates; at the finer scale of the ECoG recordings, non-REM sleep is characterized by complex SWA propagation patterns.

Item Type: Paper
Uncontrolled Keywords: neocortical neurons in-vivo oscillations state eeg ripples network cortex memory synchronization
Subjects: organism description > animal behavior > REM sleep
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Kepecs lab
Depositing User: CSHL Librarian
Date: June 2011
Date Deposited: 09 Nov 2011 18:45
Last Modified: 02 May 2013 15:47
PMCID: PMC3145488
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15639

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