The role of Rho GTPase proteins in CNS neuronal migration

Govek, E. E., Hatten, M. E., Van Aelst, L. (June 2011) The role of Rho GTPase proteins in CNS neuronal migration. Developmental Neurobiology, 71 (6). pp. 528-553. ISSN 19328451 (ISSN)

URL: https://www.ncbi.nlm.nih.gov/pubmed/21557504
DOI: 10.1002/dneu.20850

Abstract

The architectonics of the mammalian brain arise from a remarkable range of directed cell migrations, which orchestrate the emergence of cortical neuronal layers and pattern brain circuitry. At different stages of cortical histogenesis, specific modes of cell motility are essential to the stepwise formation of cortical architecture. These movements range from interkinetic nuclear movements in the ventricular zone, to migrations of early-born, postmitotic polymorphic cells into the preplate, to the radial migration of precursors of cortical output neurons across the thickening cortical wall, and the vast, tangential migrations of interneurons from the basal forebrain into the emerging cortical layers. In all cases, actomyosin motors act in concert with cell adhesion receptor systems to provide the force and traction needed for forward movement. As key regulators of actin and microtubule cytoskeletons, cell polarity, and adhesion, the Rho GTPases play critical roles in CNS neuronal migration. This review will focus on the different types of migration in the developing neocortex and cerebellar cortex, and the role of the Rho GTPases, their regulators and effectors in these CNS migrations, with particular emphasis on their involvement in radial migration. © 2010 Wiley Periodicals, Inc.

Item Type: Paper
Uncontrolled Keywords: INTERKINETIC NUCLEAR MIGRATION DEVELOPING CEREBRAL-CORTEX NUCLEOTIDE-EXCHANGE FACTORS CELL-POLARITY PROTEIN DEVELOPING CEREBELLAR CORTEX DIEKER LISSENCEPHALY GENE ABL TRANSFORMING ACTIVITY NEURAL PROGENITOR POOL CENTRAL-NERVOUS-SYSTEM NONMUSCLE MYOSIN-II
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > tissues types and functions > brain venticular zone
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
CSHL Authors:
Communities: CSHL labs > Van Aelst lab
Depositing User: CSHL Librarian
Date: June 2011
Date Deposited: 09 Nov 2011 17:48
Last Modified: 22 Feb 2017 16:05
PMCID: PMC3188326
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15637

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving