Structural plasticity underlies experience-dependent functional plasticity of cortical circuits

Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., Svoboda, K. (2010) Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. J Neurosci, 30 (14). pp. 4927-4932. ISSN 1529-2401 (Electronic) 0270-6474 (Linking)

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URL: http://www.jneurosci.org/cgi/content/full/30/14/49...
DOI: 10.1523/JNEUROSCI.6403-09.2010

Abstract

The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.

Item Type: Paper
Subjects: organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
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Depositing User: CSHL Librarian
Date Deposited: 20 Oct 2011 13:32
Last Modified: 29 Nov 2011 20:03
PMCID: PMCID: PMC2910869
URI: http://repository.cshl.edu/id/eprint/15584

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