ΔNp73β puts the brakes on DNA repair

Vernersson-Lindahl, E., Mills, A. A. (2010) ΔNp73β puts the brakes on DNA repair. Genes Dev, 24 (6). pp. 517-20. ISSN 1549-5477 (Electronic) 0890-9369 (Linking)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/20231313
DOI: 10.1101/gad.1914210

Abstract

Mammalian cells are barraged with endogenous metabolic byproducts and environmental insults that can lead to nearly a million genomic lesions per cell per day. Networks of proteins that repair these lesions are essential for genome maintenance, and a compromise in these pathways propagates mutations that can cause aging and cancer. The p53 tumor suppressor plays a central role in repairing the effects of DNA damage, and has therefore earned the title of "guardian of the genome." In this issue of Genes & Development, Wilhelm and colleagues (pp. 549-560) demonstrate that p73-an older sibling of p53-inhibits pathways that resolve DNA double-strand breaks.

Item Type: Paper
Uncontrolled Keywords: DNA repair pathways aging cancer p53 tumor Suppressor DNA damage DNA double-strand breaks
Subjects: diseases & disorders > cancer
organism description > animal > mammal
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: CSHL Librarian
Date Deposited: 20 Oct 2011 14:27
Last Modified: 02 Feb 2017 17:00
PMCID: PMC2841329
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15577

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