Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders

Svitkina, T., Lin, W. H., Webb, D. J., Yasuda, R., Wayman, G. A., Van Aelst, L., Soderling, S. H. (2010) Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders. J Neurosci, 30 (45). pp. 14937-14942. ISSN 1529-2401 (Electronic) 0270-6474 (Linking)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/21068295
DOI: 10.1523/JNEUROSCI.4276-10.2010

Abstract

The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during experience-dependent plasticity. This mini-symposium review will feature ongoing research into how spines are regulated by actin-signaling pathways during development and plasticity. It will also highlight evolving studies into how disruptions to these pathways might be functionally coupled to congenital disorders such as mental retardation.

Item Type: Paper
Subjects: diseases & disorders > congenital hereditary genetic diseases
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Depositing User: CSHL Librarian
Date Deposited: 19 Oct 2011 14:08
Last Modified: 22 Feb 2017 16:07
PMCID: PMC3074493
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15536

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