The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits

Oviedo, H. V., Bureau, I., Svoboda, K., Zador, A. M. (October 2010) The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits. Nature Neuroscience, 13 (11). pp. 1413-1420. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/20953193
DOI: 10.1038/nn.2659

Abstract

The primary auditory cortex (A1) is organized tonotopically, with neurons sensitive to high and low frequencies arranged in a rostro-caudal gradient. We used laser scanning photostimulation in acute slices to study the organization of local excitatory connections onto layers 2 and 3 (L2/3) of the mouse A1. Consistent with the organization of other cortical regions, synaptic inputs along the isofrequency axis (orthogonal to the tonotopic axis) arose predominantly within a column. By contrast, we found that local connections along the tonotopic axis differed from those along the isofrequency axis: some input pathways to L3 (but not L2) arose predominantly out-of-column. In vivo cell-attached recordings revealed differences between the sound-responsiveness of neurons in L2 and L3. Our results are consistent with the hypothesis that auditory cortical microcircuitry is specialized to the one-dimensional representation of frequency in the auditory cortex.

Item Type: Paper
Subjects: organism description > animal behavior > auditory
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Svoboda lab
CSHL labs > Zador lab
Depositing User: CSHL Librarian
Date: 17 October 2010
Date Deposited: 05 Oct 2011 14:34
Last Modified: 02 May 2013 21:02
PMCID: PMC3140463
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15501

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