The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer

Murchison, E. P., Tovar, C., Hsu, A., Bender, H. S., Kheradpour, P., Rebbeck, C. A., Obendorf, D., Conlan, C., Bahlo, M., Blizzard, C. A., Pyecroft, S., Kreiss, A., Kellis, M., Stark, A., Harkins, T. T., Marshall Graves, J. A., Woods, G. M., Hannon, G. J., Papenfuss, A. T. (January 2010) The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer. Science, 327 (5961). pp. 84-7. ISSN 1095-9203 (Electronic) 1095-9203 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/20044575
DOI: 10.1126/science.1180616

Abstract

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.

Item Type: Paper
Uncontrolled Keywords: Tasmanian devil devil facial tumor disease DFTD transmissible cancer monophletic clonally transmissible tumor Schwann cell diagnostic marker cancer diagnosis disease evolution conservation biology
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > annotation > sequence annotation
bioinformatics > genomics and proteomics > Mapping and Rendering > Sequence Rendering
organism description > animal
organism description > animal behavior
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Hannon lab
Watson School > Publications
Depositing User: CSHL Librarian
Date: 1 January 2010
Date Deposited: 03 Oct 2011 14:56
Last Modified: 03 Jan 2019 21:36
PMCID: PMC2982769
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15489

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