Is universal coverage good for neurons?

Kolterman, B. E., Koulakov, A. A. (2010) Is universal coverage good for neurons? Neuron, 66 (1). pp. 1-3. ISSN 1097-4199 (Electronic) 0896-6273 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/20399721
DOI: 10.1016/j.neuron.2010.04.005

Abstract

Main Text The brain relies on precise connectivity to process information. It is hardly possible to specify each individual connection between the several billions of neurons in the average mammalian brain on the basis of a limited set of instructions contained in the genome. Therefore, it is often assumed that genes specify the general connectivity rules rather than specific connections. One such rule is that neurons that share similar properties project to proximal areas in the brain, leading to the emergence of brain maps. This allows wiring a large number of connections with only a few molecular markers that form gradients, such as in the case of topographic maps (McLaughlin and O'Leary, 2005 T. McLaughlin and D.D. O'Leary, Annu. Rev. Neurosci. 28 (2005), pp. 327–355. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (126)McLaughlin and O'Leary, 2005)....

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Koulakov lab
CSHL Post Doctoral Fellows
Depositing User: CSHL Librarian
Date Deposited: 03 Oct 2011 20:58
Last Modified: 02 May 2013 19:45
PMCID: PMC3023861
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15457

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