The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea

Karginov, F. V., Hannon, G. J. (2010) The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea. Molecular Cell, 37 (1). pp. 7-19.

URL: http://www.ncbi.nlm.nih.gov/pubmed/20129051
DOI: 10.1016/j.molcel.2009.12.033

Abstract

All cellular systems evolve ways to combat predators and genomic parasites. In bacteria and archaea, numerous resistance mechanisms have developed against phage. Our understanding of this defensive repertoire has recently been expanded to include the CRISPR system of clustered, regularly interspaced short palindromic repeats. In this remarkable pathway, short sequence tags from invading genetic elements are actively incorporated into the host's CRISPR locus to be transcribed and processed into a set of small RNAs that guide the destruction of foreign genetic material. Here we review the inner workings of this adaptable and heritable immune system and draw comparisons to small RNA-guided defense mechanisms in eukaryotic cells. © 2010 Elsevier Inc. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: DNA MICROBIO RNA
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > annotation > sequence annotation
organism description > bacteria
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > siRNA
CSHL Authors:
Communities: CSHL labs > Hannon lab
CSHL Post Doctoral Fellows
Depositing User: CSHL Librarian
Date Deposited: 04 Oct 2011 14:34
Last Modified: 02 May 2013 19:30
PMCID: PMC2819186
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15447

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