Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

Huang, L., Muthuswamy, S. K. (February 2010) Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Current Opinion in Genetics and Development, 20 (1). pp. 41-50.

URL: https://www.ncbi.nlm.nih.gov/pubmed/20093003
DOI: 10.1016/j.gde.2009.12.001

Abstract

In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis. © 2009 Elsevier Ltd. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: gene expression protein mislocalization polarity proteins CARCINOMA cell junction biogenesis
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: CSHL Librarian
Date: February 2010
Date Deposited: 03 Oct 2011 13:46
Last Modified: 07 Mar 2018 18:23
PMCID: PMC3015045
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15434

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