Non-germline genetically engineered mouse models for translational cancer research

Heyer, J., Kwong, L. N., Lowe, S. W., Chin, L. (July 2010) Non-germline genetically engineered mouse models for translational cancer research. Nature Reviews Cancer, 10 (7). pp. 470-480. ISSN 1474-175X

URL: https://www.ncbi.nlm.nih.gov/pubmed/20574449
DOI: 10.1038/nrc2877

Abstract

Genetically engineered mouse models (GEMMs) of cancer have affected virtually all areas of cancer research. However, the accelerated discovery of new cancer genes emerging from large-scale cancer genomics and new chemical entities pouring from the drug discovery pipeline have strained the capacity of traditional germline mouse models to provide crucial insights. This Review introduces new approaches to modelling cancer, with emphasis on a growing collection of non-germline GEMMs (nGEMMs). These offer flexibility, speed and uniformity at reduced costs, thus paving the way for much needed throughput and practical preclinical therapeutic testing models.

Item Type: Paper
Uncontrolled Keywords: GROWTH-FACTOR RECEPTOR IN-VIVO BREAST-CANCER HUMAN SKIN TUMOR MAINTENANCE MAMMALIAN-CELLS SONIC HEDGEHOG MAMMARY-TUMORS LIVER-CANCER K-RAS
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: CSHL Librarian
Date: July 2010
Date Deposited: 03 Oct 2011 14:08
Last Modified: 07 Mar 2018 18:02
PMCID: PMC4602412
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15430

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