Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse

Dhawale, A. K., Hagiwara, A., Bhalla, U. S., Murthy, V. N., Albeanu, D. F. (2010) Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse. Nature Neuroscience, 13. pp. 1404-12. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/20953197
DOI: 10.1038/nn.2673

Abstract

Sensory inputs frequently converge on the brain in a spatially organized manner, often with overlapping inputs to multiple target neurons. Whether the responses of target neurons with common inputs become decorrelated depends on the contribution of local circuit interactions. We addressed this issue in the olfactory system using newly generated transgenic mice that express channelrhodopsin-2 in all of the olfactory sensory neurons. By selectively stimulating individual glomeruli with light, we identified mitral/tufted cells that receive common input (sister cells). Sister cells had highly correlated responses to odors, as measured by average spike rates, but their spike timing in relation to respiration was differentially altered. In contrast, non-sister cells correlated poorly on both of these measures. We suggest that sister mitral/tufted cells carry two different channels of information: average activity representing shared glomerular input and phase-specific information that refines odor representations and is substantially independent for sister cells.

Item Type: Paper
Subjects: organism description > animal behavior
organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal behavior > odor recognition
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal
CSHL Authors:
Communities: CSHL labs > Albeanu lab
Depositing User: CSHL Librarian
Date Deposited: 29 Sep 2011 20:01
Last Modified: 04 Dec 2014 16:39
PMCID: PMC3208311
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15400

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