Noncoding RNAs and gene silencing

Zaratiegui, B. M., Irvine, D. V., Martienssen, R. A. (February 2007) Noncoding RNAs and gene silencing. Cell, 128 (4). pp. 763-76. ISSN 0092-8674 (Print)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/17320512
DOI: 10.1016/j.cell.2007.02.016

Abstract

Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is discussed, as well as parallels with RNA silencing in imprinting, paramutation, polycomb silencing, and X inactivation. Interactions with regulatory sequences may well occur, but at the RNA rather than at the DNA level.

Item Type: Paper
Uncontrolled Keywords: Animals DNA Transposable Elements/genetics Epigenesis, Genetic/ genetics Gene Expression Regulation/ genetics Gene Silencing/ physiology Humans RNA Interference/physiology RNA, Untranslated/ genetics Repressor Proteins/genetics/metabolism X Chromosome Inactivation/genetics
Subjects: bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics

organism description > animal > mammal > primates > hominids > human
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: CSHL Librarian
Date: 23 February 2007
Date Deposited: 30 Aug 2011 18:52
Last Modified: 05 Jun 2013 15:23
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15287

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