Segregation of odor identity and intensity during odor discrimination in Drosophila mushroom body

Xia, S., Tully, T. (October 2007) Segregation of odor identity and intensity during odor discrimination in Drosophila mushroom body. PLoS Biology, 5 (10). e264.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/17914903
DOI: 10.1371/journal.pbio.0050264

Abstract

Molecular and cellular studies have begun to unravel a neurobiological basis of olfactory processing, which appears conserved among vertebrate and invertebrate species. Studies have shown clearly that experience-dependent coding of odor identity occurs in "associative" olfactory centers (the piriform cortex in mammals and the mushroom body [MB] in insects). What remains unclear, however, is whether associative centers also mediate innate (spontaneous) odor discrimination and how ongoing experience modifies odor discrimination. Here we show in naive flies that Galphaq-mediated signaling in MB modulates spontaneous discrimination of odor identity but not odor intensity (concentration). In contrast, experience-dependent modification (conditioning) of both odor identity and intensity occurs in MB exclusively via Galphas-mediated signaling. Our data suggest that spontaneous responses to odor identity and odor intensity discrimination are segregated at the MB level, and neural activity from MB further modulates olfactory processing by experience-independent Galphaq-dependent encoding of odor identity and by experience-induced Galphas-dependent encoding of odor intensity and identity.

Item Type: Paper
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > odor recognition
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: CSHL Librarian
Date: 2 October 2007
Date Deposited: 30 Aug 2011 22:04
Last Modified: 11 Apr 2018 14:32
PMCID: PMC1994992
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15279

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